By multiple regression analysis, MDA, ROS, TBARS, AOPP, SOD 1, SOD 2, SOD 3, and PON 1 were found to be independent risk indicators for the MCI+MCTCO after adjustment for gender, age, CAD, TIA, FHOS, HT, DM, PVD, smoking, AC, MI, AP, and DOI in elderly patients. The gene discussed is PON1; the disease is coronary artery disorder.