Our results suggested that the increased prooxidant status (MDA, ROS, TBARS, and AOPP) contributed to the differentiation of monocytes into macrophages to oxidize lipids (OX-LDL) in atherosclerosis lesions of the arterial walls and subsequently arterial foam cell formation involving the progression of cerebral and coronary artery steno-occlusion through inhibiting the expressions of antioxidant enzymes (SOD 1, SOD 2, SOD 3, and PON 1). Here, PON1 is linked to atherosclerosis.