Plenty of evidences suggest that cerebrospinal fluid (CSF) amyloid β 42 (Aβ42), total tau (T-tau), and phospho-tau (P-tau) are biomarkers of the POD process, reflecting plaque pathology, neurodegeneration, and neurofibrillary tangle pathology, respectively (Maldonado, 2013). This evidence concerns the gene MAPT and Neurofibrillary tangles.