In addition, IGFBP-1, which was significantly lower in Dem-Alzheimer's disease compared with CN individuals, was also significantly lower in Dem-Alzheimer's disease compared with Dem-Other (fold-change = 0.63, P = 0.03), suggesting the change maybe unique to Alzheimer's disease pathology. Here, IGFBP1 is linked to early-onset autosomal dominant Alzheimer disease.