Consistent with its known association with multiple neurodegenerative diseases,6,8,32 NF-L was highly increased in Dem-Other (fold-change = 2.03, P = 4.43 × 10−10) and moderately in Dem-Alzheimer's disease (fold-change = 1.29, P = 0.029) versus CN participants. The gene discussed is NEFL; the disease is early-onset autosomal dominant Alzheimer disease.