With regard to neurodegeneration, plasma neurofilament light polypeptide (NF-L, gene name NEFL) has been extensively studied and is associated with risk of developing Alzheimer's disease and non-Alzheimer's disease dementia,5 with Alzheimer's disease diagnosis, as well as positive Alzheimer's disease imaging biomarkers.6 However, the utility of blood-based ATN biomarkers in predicting MCI progression remains indefinite. Here, TYR is linked to early-onset autosomal dominant Alzheimer disease.