NLRP3 and cryopyrin-associated periodic syndrome: A well-established causal relationship between gain of function mutations of NLRP3, resulting in excessive inflammasome activation with subsequent overproduction of IL-1β, and disease can be found for autoinflammatory conditions called cryopyrin-associated periodic syndromes (CAPS) (Caseley et al., 2020; Welzel and Kuemmerle-Deschner, 2021).