FN1 and neoplasm: Cells adhere to RGD motifs expressed on fibronectin via the α5β1 receptor and αVβ3 which have emerged as essential mediators in many human carcinomas and are largely implicated in tumour proliferation and metastasis, with αVβ3 identified as a melanoma tumour progression marker (Hsu et al., 1998; Koistinen and Heino, 2013; Hou et al., 2020).