FN1 and neoplasm: Tumor progression also proceeds extensive modification to ECM composition (i.e., going from fibronectin-laminin rich matrix to primarily collagen dominated) which alters the integrin profile and at the nanoscale alters the spacing at which cells are interacting with ECM proteins (Sherman-Baust et al., 2003; Allinen et al., 2004; Paszek and Weaver, 2004; Larsen et al., 2006; Gierach et al., 2012; Oskarsson, 2013).