In this review, we mainly concentrate on several typical molecules including Nrf2 (Sun et al., 2016b), S1R (Bai et al., 2019), HSPB1 (Sun et al., 2015), MT-1G (Sun et al., 2016a), p53 (Jiang et al., 2015; Jennis et al., 2016), YAP/TAZ (Gao et al., 2021), TGF-β1 (Kim et al., 2020), IFNγ (Kong et al., 2021), Rb (Louandre et al., 2015), and the high-LET CI (Zheng et al., 2022) (Table 1), and narrate how they are involved in regulation of ferroptosis in HCC (Figure 2). The gene discussed is WWTR1; the disease is hepatocellular carcinoma.