Evidences showed that ATF4 inhibition promoted the ferroptosis process induced by sorafenib in HCC with increased lipid peroxidation, decreased GSH, and decreased cell viability, which could be suppressed by ferrostatin-1 as well as forced expression of SLC7A11, suggesting that ATF4 was involved in resistance to ferroptosis in HCC through the regulation of SLC7A11. This evidence concerns the gene ATF4 and hepatocellular carcinoma.