PRKCG and Ataxia: Thus, whereas the aforementioned previous studies have proposed a variety of mechanisms that may be involved in the cerebellar degeneration that is characteristic of ataxia, the previously established correlation between enhanced basal activity of PKCγ variants with age of disease onset support a model in which increased PKCγ signaling in the absence of second messengers likely drives SCA14 (Pilo et al., 2022).