YBX1 and cancer: On the other hand, YB-1 displays a nuclear localization in aggressive types of cancer resistant to chemotherapy which influences the sensitivity of cancer cells to anticancer drugs and the efficiency of chemotherapy (Bargou et al., 1997; Shibahara et al., 2001; Matsumoto and Bay, 2005; Kosnopfel et al., 2014; Bates et al., 2020).