Meanwhile, we found that C5AR1, CCL4L2, CCL4, CCL20, CD163, CXCL3, and CXCL12 were only expressed in disease a (Figure 3H and Supplementary Figure S4D), suggesting the recruitment of inflammatory factors and promotion of the inflammatory response were both more obvious in hypertension-induced AD. Here, CCL4 is linked to Alzheimer disease.