In conclusion, the Janus kinase 2 mutation polycythaemia vera is frequently associated with venous thrombosis and has also been reported to cause intracardiac and portal vein thrombosis. EkoSonicTM endovascular system-directed thrombolysis is effective in short-term symptomatic relief of patients with large pulmonary embolism, but long-term benefits need further studies. This evidence concerns the gene JAK2 and acquired polycythemia vera.