DAPA on top of renin-angiotensin-aldosterone system (RAAS) blocking medication produced neutral renal hemodynamic and antiproteinuric effects in non-diabetic patients with focal segmental glomerulosclerosis (FSGS), according to the initial pilot trial by Rajasekeran et al., which included 10 non-diabetic patients [38]. This evidence concerns the gene REN and focal segmental glomerulosclerosis.