MMP2 and leiomyoma: The significant inhibitory effect of curcumin on the expression of ECM receptors in non-small-cell lung cancer (Li et al., 2017) and reducing the activity of MMP-2 and up-regulating TIMP activity in various cancer cells (Mitra et al., 2006; Hassan and Daghestani, 2012; Supriono et al., 2018) suggest the possible mechanism of curcumin in producing anti-uterine fibroid activity via reducing the ECM production, thus further study investigating the effects of curcumin on various ECM-related receptors and proteins in leiomyoma cells may be conducted.