NR1H4 and colorectal cancer: High deoxycholic acid (DCA) levels have been associated with low BMD in people over 60 (Jovanovich et al., 2018), with colorectal cancer (Bayerdörffer et al., 1995), and with gut dysbiosis, intestinal inflammation, increased bile acid pool, and lower intestinal FXR activity (Wang et al., 2020; Xu et al., 2021a; Xu et al., 2021b).