Through the target intersection of active ingredients and diseases of PMS/PMDD, we obtained CHRM1/CHRM2/CHRM3/CHRM4/CHRM5, SLC6A2/SLC6A3/SLC6A4, ADRA1A/ADRA1B/ADRA1D/ADRA2A/ADRA2B/ADRA2C, ESR1/ESR2, and DRD1/DRD2 and other 26 intersection targets, mainly belonging to solute carrier family 6, cholinergic receptor, adrenergic receptor, estrogen receptor, and dopamine receptor families (Supplementary Table S6). The gene discussed is ESR2; the disease is premenstrual tension.