On the other hand, the existing network of pharmacological studies on the depression mechanism of action of commonly used single drugs such as Bupleurum Chinensis DC and Radix Paeoniae Alba has revealed that they primarily contain active ingredients such as β-sitosterol, sitosterol, and flavonoids, with the primary targets being ADRA2A, ESR1, ADRA1B, and SLC6A4 (Chang et al., 2020). Here, SLC6A4 is linked to depressive disorder.