NFKB1 and osteoarthritis: Activation of the NF-κB pathway can give rise to chondrocyte-related inflammation responses and the production of MMPs, while the MAPK pathway also serves an important role in ECM metabolic imbalance and cartilage degradation, and the former has been considered a prospective therapy target in osteoarthritis (Roman-Blas and Jimenez, 2006; Malemud, 2017; Zhou et al., 2019).