Similar to the replication competent SINV Toto1101/luc, infection with the replication-deficient SINV Toto1101/luc:ts6 generally results in higher expression of ZAP and TRIM25 variants (Supplemental Figure 3), though the phenotype for a 6 hour infection is not as robust as a 24 hour infection. Here, ZC3HAV1 is linked to infection.