The study also found that the supernatants of L. gasseri, L. crispatus, and L. jensenii can downregulate the expression of HPV oncogene E6 and E7, cyclin A, and cyclin-dependent kinase 2 (CDK2) to inhibit the activity of cervical cancer cells (Ghanavati et al., 2020). This evidence concerns the gene CCNA2 and cervical cancer.