Another study has shown that a supernatant cultured with L. crispatus and L. rhamnosus can reduce the expression of autophagy genes ATG14, BECN1, and HPV E6 oncogene to create an anti-proliferative effect on HeLa cervical cancer cells (Motevaseli et al., 2016). The gene discussed is BECN1; the disease is cervical carcinoma.