Several studies have correlated type I interferon concentration in infected patients with the severity of dengue and Zika disease with controversial and, in some cases, contradictory results, such as the study by Talarico et al., where they demonstrate that higher levels of IFNα or IFNβ in sera can correlate with the severity of dengue disease in pediatric patients from Paraguay (Talarico et al., 2017); in contrast, the study by De la Cruz Hernandez et al. Here, IFNA2 is linked to dengue disease.