It has been reported that infection of dermal fibroblasts induces activation of innate immune responses like secretion of IFNβ and other soluble mediators that could be key to the establishment of the antiviral and pro-inflammatory microenvironment that could shape the activation status of immune cells like dendritic cells (Kurane et al., 1992; Bustos-Arriaga et al., 2011; Hamel et al., 2015; Bustos-Arriaga et al., 2016; Kim et al., 2019). The gene discussed is IFNB1; the disease is infection.