The present report correlates with a prior study from the same province in KSA that had shown higher rates of infection in individuals with blood group O (Alzahrani et al., 2018)., which could be due to lower serum concentrations of von Willebrand factor (vWF) and factor VIII (FVIII) in this group (Yamamoto et al., 2021). This evidence concerns the gene F8 and infection.