The known association of MAP3K1, PIK3CA, and TP53 mutations with poor prognosis in luminal A and luminal B subtypes of breast cancer, using targeted sequencing, Griffith et al.[27] reported the significant association of frameshift nonsense (FS/NS) mutations in NF1 and variants of unknown significance in PIK3R1 and DDR1 as a marker for poor prognosis and resistance in oestrogen receptor-positive breast cancer cohort[27-28]. The gene discussed is PIK3R1; the disease is breast carcinoma.