Furthermore, in high-risk childhood ALL patients, including patients with MLL gene rearrangement, blasts cells were within three different maturation stages (CD34+CD19-, CD34+CD19+ and CD34-CD19+), which all had the capacity to re-establish and reconstitute the original leukemia phenotype in NOD/SCID mice[154]. This evidence concerns the gene KMT2A and acute lymphoblastic leukemia.