While 2-HG was shown to drive CPT1a and CEBPα-dependent FAO and OXPHOS, abrogation of 2-HG production by IDH inhibitor did not impact FAO rate or OXPHOS in the treated AML cell lines, suggesting maintenance of OXPHOS phenotype independent of 2-HG[27]. The gene discussed is IDH2; the disease is acute myeloid leukemia.