FBN1 and ovarian cancer: Another study has shown that fibrillin-1 (FBN1) is significantly upregulated in cisplatin-resistant ovarian cancer organoids and tissues and that FBN1 drives phosphorylation of VEGF2 and nuclear translocation of the transcription factor signal transducer and activator of transcription 2 (STAT2), which affects the expression of genes associated with STAT2-mediated glycolysis and angiogenesis[34].