MED1 and cancer: This was further supported by several other findings including marked reductions in phosphorylation of IGF-1 signaling pathway proteins including the IGF-1 receptor, AKT, and mTOR in MED1 mutant tumors, phenocopying of IGF-1R inhibition and MED1 mutations in both mouse and human cancer cells, and correlation of MED1 and IGF-1 protein levels in human clinical samples.