Furthermore, stable overexpression of the caspase-9 inhibitors, caspase-9S and X-linked inhibitor of apoptosis (XIAP) in the NSCLC cell line H460 failed to suppress apoptosis induced by various chemotherapeutic drugs; however, drug-induced apoptosis was blocked in H460 transfectants that expressed known inhibitors of caspase-8[22]. The gene discussed is CASP9; the disease is non-small cell lung carcinoma.