In Fms-related receptor tyrosine kinase (FLT)3-ITD (a mutation in the tyrosine kinase domain) expressing acute myeloid leukemia, NADPH oxidase 4 generated ROS will inactivate the protein-tyrosine phosphatase (PTP) DEP-1/PTPRJ, which negatively regulates FLT3-ITD transformation[55]. This evidence concerns the gene FLT3 and acute myeloid leukemia.