In Fms-related receptor tyrosine kinase (FLT)3-ITD (a mutation in the tyrosine kinase domain) expressing acute myeloid leukemia, NADPH oxidase 4 generated ROS will inactivate the protein-tyrosine phosphatase (PTP) DEP-1/PTPRJ, which negatively regulates FLT3-ITD transformation[55]. The gene discussed is PTPRJ; the disease is acute myeloid leukemia.