Moreover, in diabetic βV59M mice (a non-obese, eu-lipidaemic diabetes model with suppressed insulin secretion), in which tamoxifen-inducible expression of a constitutively open KATP channel specifically in pancreatic β cells, the ATP synthesis rate and insulin secretion are markedly reduced in the islet β cells when compared with that in wild type mice (Haythorne et al., 2019). The gene discussed is INS; the disease is diabetes mellitus.