Hepatic miR-423-5p overexpression inhibits FAM3A-ATP-P2R signaling pathway to promote hyperglycemia, insulin resistance and steatosis in normal mice, while miR-423-5p inhibition activated FAM3A-ATP-P2R signaling pathway to ameliorate hyperglycemia and fatty liver in obese mice (Yang et al., 2017). This evidence concerns the gene FAM3A and Insulin resistance.