Generally, when insulin resistance occurs, islet β cell compensates for insulin insufficiency by increasing insulin secretion ability of individual cell or by proliferating, once pancreatic islet β cells fail to compensate for insulin resistance, hyperglycemia will be established (Biddinger and Kahn, 2006; Bensellam et al., 2018; Holst et al., 2018). Here, INS is linked to Insulin resistance.