SREBF1 and acne: A high intake of these “danger signals” can activate the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1), which stimulates sterol response element binding protein-1 (SREBP-1) and then upregulates stearoyl-CoA-desaturase (SCD), enhancing the proportion of MUFA in sebum triglycerides during the pathogenesis of acne (Melnik, 2015).