IL33 and cutaneous mastocytosis: The association of elevated plasma sST2 levels with endothelial activation, inflammation, neuronal injury, and long-term neurocognitive impairment in children with CM supports further investigation of exogenous IL-33 or IL-33 analogs to suppress the pro-inflammatory response elicited by sST2 in murine or non-human primate models, to evaluate how the timing and dose of administration impact disease outcomes and host response in a model.