Interestingly, the vascular endothelial growth factor (VEGF), HIF-1α (Hypoxia Inducible Factor-1), microvascular decompression (MVD), and vascular endothelial growth factor-2 (VEGF-2) were all underexpressed in group A, B, and C, compared with control suggesting that DSS-spleen tonics and Regorafenib share the same target in HCC xenograft model (Figure 3(a)). Here, HIF1A is linked to hepatocellular carcinoma.