Nuclear factor Kappa B (NF-κB) has also been reported to be a prominent signaling molecule in the pathogenesis of skeletal muscle atrophy, and many muscular atrophy-related genes, including MuRF1, MyoD, and cyclin D ubiquitin-binding enzyme (E2), are its target gene [34]. The gene discussed is MYOD1; the disease is Skeletal muscle atrophy.