The variable BDNF × CKD status was found to contribute to the multivariable logistic regression model (odds ratio = 6.413, 95% CI: 1.497–27.47) and Cox regression model (hazard ratio = 3.640, 95% CI: 1.006–13.173) after adjusting for age and UACR. This evidence concerns the gene BDNF and chronic kidney disease.