TNF and thrombophilia: Third, previous studies have shown that disorders of glucolipid metabolism can induce the release of pro-inflammatory factors, such as tumor necrosis factor-α and interleukin-6 (54), cause blood hypercoagulability, damage vascular endothelial cells, and participate in and promote the development of atherosclerosis (55, 56), which are key components of the pathogenesis of CVD (57).