To achieve that, ovarian cancer SKOV-3 cells were treated with or without sorafenib (10 μM), transforming growth factor (TGF)-β1 (10 ng/mL), sorafenib (10 μM) + TGF-β1 (10 ng/mL), and TGF-β1 (10 ng/mL) + Ly2157299 (5 μM), followed by 8-Gy radiation. The gene discussed is TGFB1; the disease is ovarian cancer.