Intramolecular complex and gene activation function of EZH2 in cancer cells. In the catalytic module of PRC2, the SANT1 (SWI3, ADA2, N-CoR, and TFIIIB 1) domain and the SBD (SANT1-binding domain) of EZH2 mediate intramolecular interactions (Figure 4B) (138, 139). This evidence concerns the gene EZH2 and cancer.