In line with its role in tumor suppression, loss-of-function of PRC2 caused by inactivating mutations or chromosomal translocation of essential components of PRC2, including EZH2, EED, and SUZ12, is frequently found in myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN), T cell acute lymphoblastic leukemia (T-ALL), and malignant peripheral nerve sheath tumors (MPNSTs) (17, 68). Here, EZH2 is linked to myeloproliferative disorder.