Furthermore, EZH2 expression is correlated with active cell proliferation, and EZH2 is often aberrantly overexpressed in a number of cancer types, such as breast cancer, prostate cancer, endometrial cancer, melanoma, glioblastoma, ovarian cancer, lung cancer, and so on, where tumor suppressor genes, DNA damage repair genes, and cell signaling genes are among the targets of PRC2 (17, 67–69). This evidence concerns the gene EZH2 and Familial prostate cancer.