IFNG and neoplasm: Successful expansion of tumor-reactive tumor-infiltrating lymphocytes (TIL) from lymph nodal metastasis of penile cancer patients, with 46.8% of CD8+ T cells and 45.4% from expanded TIL secreting IFN-γ in response to autologous tumor, supports the development of ACT strategies using TIL for the treatment of advanced and recurrent penile cancer (74).