One of the largest series, with 112 patients, showed that 44% had high expression of EGFR by immunohistochemistry, despite histologic subtype, histologic grade, or HPV status (19), and since KRAS mutations (which confers resistance to EGFR blockage in cancer treatment) are rare in these tumors (20), EGFR inhibitors have a potential role as systemic treatment. This evidence concerns the gene EGFR and cancer.