The combined therapy with two classes of checkpoint inhibitors, anti-PD-1/PD-L1 and anti-CTLA4 antibodies, can improve the response to immunotherapy, as the blockage of B7-CTLA-4 pathway leads to increased activation of CD8+ cells in the lymph nodes as well as increased infiltration of activated CD8+ T cells into the tumor, which enhances the antitumor immunity induced by anti-PD-1/PD-L1 drugs (33). The gene discussed is CD274; the disease is neoplasm.