PARP1 and neoplasm: Two mutation signatures were also identified in this study: the APOBEC-related signature, with a higher tumor mutational burden (TMB) with great potential to benefit from immunotherapy with checkpoint inhibitors, and the defective DNA repair system signature, which involves mutations in BRCA1, BRCA2, ARID1A, ATR, CHEK2, PARP1, FANCA, PALB2, and RAD51, a favorable scenario for treatment with immunotherapy and PARP inhibitors.