CD274 and anal carcinoma: M7824 is an innovative first-in-class bifunctional fusion protein composed of a human IgG1 monoclonal antibody against PD-L1 fused with two extracellular domains of TGF-bRII (a TGF-b “trap”) (58) that have demonstrated signs of efficacy in a phase I trial, with one complete response and partial responses in other cervical and anal cancer patients, that are HPV related tumors with histologic similarities to penile SCC.