Recently presented results of PERICLES phase II trial (NCT03686332), which included 32 patients with advanced penile cancer treated with atezolizumab, an anti-PD-L1 monoclonal antibody, alone or associated with local radiotherapy, showed a 30% oobjective response rate among 10 evaluable patients for response by RECIST 1.1 (including two complete responses), but the trial did not reach the expected PFS, its primary endpoint. Here, CD274 is linked to penile cancer.