The strong association of the CREB transcription factor promoting miRNAs in the development and progression of gastric cancer metastasis was reported by Liu et al., where overexpression of CREB was associated with the loss of the tumor-suppressive mir-520b/GATA6 signaling axis, thereby promoting migration and metastasis of gastric cancer cells (54). The gene discussed is CREB1; the disease is gastric cancer.