Some of these differentially expressed mRNAs were involved in immunity or PI3K-Akt signaling pathways, such as EREG, TNFAIP3 and RHOB. In addition, we noted that some of these genes were associated with brain function or related disorders, such as neuronal development (C3orf70, DOK6, GRIN2B), cognitive or intellectual disorder (RAI2, ARPP21), schizophrenia and Alzheimer's disease (SEMA3A), and epilepsy (NEXMIF, KCNC2, SAMD12, GRIN2B). The gene discussed is RHOB; the disease is early-onset autosomal dominant Alzheimer disease.