Previous studies have reported that Ruscogenin can mitigate blood-brain barrier dysfunction induced by cerebral ischemia through the inhibition of the MAPK pathway and TXNIP/NLRP3 inflammasome [23], and MDG-1 (also named Ophiopogon japonicas polysaccharides), another component of Ophiopogon japonicas, has been confirmed to alleviate symptoms of SS [16]. The gene discussed is NLRP3; the disease is brain ischemia.