In conditions of hyperglycemia and oxidative stress, activated mTORC1 pathway can regulate podocyte mRNA translation, ribosomal biosynthesis, and protein translation through two key downstream effectors p70 S6 kinase (p70S6K) and 4E-binding protein 1 (4EBP1), thereby inhibiting autophagy [39, 40]. The gene discussed is EIF4EBP1; the disease is Hyperglycemia.