MAPT and Alzheimer disease: While an AD mouse model in which the deposition of both Aβ and tau occurs in a similar manner to that observed in sporadic AD patients has not yet been established, cats, dogs, wolverine, and nonhuman primates spontaneously develop age-dependent AD-like brain pathologies (Nakamura et al., 1995; Roertgen et al., 1996; Vite and Head, 2014).