Gene cluster A can be identified as a hot immune subtype, characterized by better prognosis, high expression levels of immune-related genes, and low mutation frequencies of IDH1 and ATRX. A recent study showed that IDH1 and ATRX mutations can regulate the innate immune response in gliomas, which also enhances the invasiveness of gliomas and facilitates glioma development (44, 45). This evidence concerns the gene ATRX and glioma.