ATRX and central nervous system cancer: Gene cluster A can be identified as a hot immune subtype, characterized by better prognosis, high expression levels of immune-related genes, and low mutation frequencies of IDH1 and ATRX. A recent study showed that IDH1 and ATRX mutations can regulate the innate immune response in gliomas, which also enhances the invasiveness of gliomas and facilitates glioma development (44, 45).