Following the calculation of the nodes’ topological features in the network (the median values of “Degree”, “Betweenness”, and “Closeness” were 7.0000, 0.0009, and 0.2860, respectively), four BHGZD candidate targets (PI3K, AKT1, NFκB, and IL-1β) against active RA (Figure 1I, and Supplementary Table S6) were identified due to their topological importance. The gene discussed is IL1B; the disease is rheumatoid arthritis.