TLR4 and rheumatoid arthritis: The current study performed an integrative research combining UFLC-Q-TOF-MS/MS, gene expression profiling, network calculation, pharmacokinetic profiling, SPR/MST assay, and pharmacological experiment validations, and identified TLR4/PI3K/AKT/NFκB/NLRP3 signaling-induced pyroptosis as one of the candidate effective targets of BHGZD for reversing the imbalance network of “immune-inflammation” during active RA progression.