Similar to the BHGZD formula, the two-BAC combination treatment of MG and CA may exert satisfying therapeutic efficacy on both in vivo and in vitro experiments via regulating TLR4/PI3K/AKT/NFκB signaling, which plays a vital role in synovial inflammation, cartilage degradation, and bone erosion by regulating inflammation response, immune disorder cells, and pyroptosis (37, 49–52). This evidence concerns the gene AKT1 and immune system disorder.