TLR4 and rheumatoid arthritis: In conclusion, our data offer an evidence that the MG and CA combination from BHGZD may interact with TLR4/PI3K/AKT/NFκB signaling to inhibit NLRP3 inflammasome activation and modulate pyroptosis, which provides the novel representative BACs and pharmacological mechanisms of BHGZD against active RA (Figure 7).