Following the calculation of the nodes’ topological features in the network (the median values of “Degree”, “Betweenness”, and “Closeness” were 7.0000, 0.0009, and 0.2860, respectively), four BHGZD candidate targets (PI3K, AKT1, NFκB, and IL-1β) against active RA (Figure 1I, and Supplementary Table S6) were identified due to their topological importance. This evidence concerns the gene AKT1 and rheumatoid arthritis.