Based on the fold change (fold change > 1.8 in male SLE compared with female SLE) and P value (p < 0.05), we selected the top 6 proteins (ELANE, CD14, PGAM1, S100A11, SERPINB10, and BST2) that involved in neutrophil activation and performed western blot to verify our proteomic finding. This evidence concerns the gene ELANE and systemic lupus erythematosus.