Based on the fold change (fold change > 1.8 in male SLE compared with female SLE) and P value (p < 0.05), we selected the top 6 proteins (ELANE, CD14, PGAM1, S100A11, SERPINB10, and BST2) that involved in neutrophil activation and performed western blot to verify our proteomic finding. Here, CD14 is linked to systemic lupus erythematosus.