IL1B and Behcet disease: IL-1β, a proinflammatory factor, is mainly secreted by monocytes, macrophages, and dendritic cells (DCs) and can induce the release of various inflammatory chemokines and promote the production of immune inflammation (25) IL-1β is highly expressed in the serum of patients with BD, and targeted inhibition of IL-1β has also been shown to be effective in the treatment of BD (41).