Currently, multiple cytokine-cytokine receptors interactions, such as IL-23 and IL-23R, TNF-α and TNFR1 or TNFR2, and IL-17A or Il-17F and IL-17RA or IL-17RC, have been confirmed in BD (2, 30, 31). The gene discussed is IL17A; the disease is Behcet disease.