CRVO brings structural and functional changes to the retinal capillaries and damages the blood-retinal barrier by inducing varying degrees of hypoxia in the retina, eventually leading to retinal edema as macromolecules pass through the capillaries into the retina.1-3,10,11 Hypoxia and ischemia in the retina can increase VEGF expression, promote vasopermeability and result in ME, which entails a risk of loss of visual acuity.11-13. Here, VEGFA is linked to ischemia.