VEGFA and macular retinal edema: Central retinal vein occlusion (CRVO) is a retinal vascular disorder, and non-ischemic CRVO is a clinically common condition that can lead to macular edema (ME), a major cause of visual impairment and even loss of visual acuity.1-3 ME patients were largely administered with conbercept, a vascular endothelial growth factor (VEGF) inhibitor proven to produce desired therapeutic effect in treating neovascularization in fundus and relieve ME based on a multiple-dosing regimen.4-6