VEGFA and diabetes mellitus: Therefore, this technique is ideal for patients with non-ischemic CRVO-induced ME and is shown to yield better outcomes when used in combination with anti-VEGF agents.9,16 In a prospective study of patients with diabetic macular edema who did not respond to anti-VEGF therapy, micropulsed laser therapy improved BCVA and CMT in patients with anti-VEGF-resistant diabetes.17 The results of Bougatsou P et al.18 also showed that micropulse laser has a significant role in the treatment of non-centrally involved and clinically significant macular edema.