Abnormalities in thyroid function, especially subclinical hypothyroidism, is highly prevalent in Pakistan2,3 and one of its major contributing factors is low awareness about the symptoms among people as well as physicians Thyroid Hormone (TH) receptors are found in highest concentration in developing neurons of fetal brain as they are indispensable for the normal growth of both humans and animal brains.4 It is a consistent finding of innumerable experimental studies that brain is the main organ which is extremely sensitive to the serum concentration of thyroid hormones.5 The gene discussed is TG; the disease is thyroid gland disorder.