Fig.3 presents LS mean % changes in serum CTX and PINP. The change in baseline levels of these bone markers was not significant across 4 groups. The LS mean changes in PINP values among acute ADT group, chronic ADT group, former ADT group, and PCa controls group were −8.31%, +1.52%, +11.93%, and −3.41%, respectively. Whereas for serum CTX,, LS mean baseline changes were −10.73%, +3.55%, −6.52%, and +2.17%, for the corresponding groups respectively. (Fig.3). The gene discussed is CYP27A1; the disease is posterior cortical atrophy.