HIF1A and macular retinal edema: Moreover, the AUC of HIF-1α mRNA in the aqueous humor in the diagnosis of CRVO combined with macular edema was 0.888, with the cutoff value of 1.501 and high diagnostic specificity (95.9%), which indicates that the risk of CRVO combined with macular edema is high when HIF-1α mRNA level > 1.501.