It is speculated that miR-210 and HIF-1α may be related to the pathogenesis of CRVO combined with macular edema.7 Therefore, in this study, the expression levels of miR-210 and HIF-1α in patients with CRVO combined with macular edema were detected, and their correlations with CRVO combined with macular edema were explored, so as to provide reference for controlling disease progression and improving the vision of patients. Here, HIF1A is linked to macular retinal edema.