Pearson’s correlation analysis showed that in the CRVO combined with macular edema group, HIF-1α mRNA and miR-210 levels in the aqueous humor were positively correlated (r = 0.522, P < 0.05), and they were both positively correlated with MCP-1, VEGF and IL-6 levels (P < 0.05) (Table-IV, Fig.1). The gene discussed is VEGFA; the disease is macular retinal edema.