The results demonstrated that the area under the curve (AUC) of HIF-1α mRNA and miR-210 in the aqueous humor in diagnosing CRVO combined with macular edema was 0.888 (95%CI: 0.829-0.947) and 0.866 (95%CI: 0.804-0.927), the cutoff value was 1.501 and 1.315, the specificity was 95.9% and 85.1%, and the sensitivity was 76.9% and 80.0%, respectively. The gene discussed is HIF1A; the disease is macular retinal edema.