The AUC of their combination was 0.937 (95%CI: 0.896-0.978), with the specificity of 93.2% and the sensitivity of 86.2% (Fig.2).Multivariate logistic regression analysis was carried out with CRVO combined with macular edema as the dependent variable, and HIF-1α, miR-210, MCP-1, VEGF and IL-6 levels as independent variables, revealing that HIF-1α, miR-210 and VEGF were the independent risk factors affecting the occurrence of CRVO combined with macular edema, as seen in Table-V (P < 0.05). This evidence concerns the gene HIF1A and macular retinal edema.