Functional impairment or decrease in glomerular podocytes is suggested to induce elevated urinary albumin excretion and glomerulosclerosis.20 Complexes in podocyte foot processes (FPs) are composed of various proteins such as PCX and nephrin to maintain morphological and functional characteristics of podocytes and form a glomerular filtration barrier. The gene discussed is NPHS1; the disease is glomerulosclerosis.